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Data availability Human renal gene expression data were obtained by merging scRNA data from KPMP and the Human Kidney Single Cell Transcriptome using a tool publicly provided by the Susztak Lab ( Source data are provided

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Rate constants for mammalian glutaredoxins and poplar GrxS12 range from 2.5 × 10 4 to 2 × 10 6 M −1 s −1 and also support a rate-limiting reductive half-reaction 19,20,21,37